Retrospective case note review 1988-2003. No control Retrospective case note review Missing data No record of concomitant treatment Descriptive statistics only.ġ4 cases of ingestion or inhalation of cyanide salts (mean age 35.2 years) ROSC only: 21/38 arrested patients had ROSC on scene, 2/21 survived (2%). Intervention: Median dose 5g hydroxocobalamin IV pre hospital (R1-10g)

Retrospective case note review 1995-2003 using Paris Fire Brigade records. No Control Deaths confirmed at scene excluded from study No record of concomitant drugs/ interventions High number of patients received hyperbaric oxygen (57/69) Descriptive statistics only.ġ01 patients administered hydroxocobalamin pre hospital between 19 (median age 48.5). 2/15 survived cardiac arrest to discharge. Haemodynamic Status: 54/69 patients had a spontaneous circulation initially 15/69 were in cardiac arrest. Survival: 50/69 overall survival 67% in those with confirmed cyanide poisoning. Prospective Observational Case Series (1987 – 1994). Relevant Paper(s) Author, date and countryĦ9 inhalation injury victims (mean age 49.6y). Search Strategy: ((Cyanides OR cyanide) AND (Hydroxocobalamin) AND (inhalation OR ingestion OR fires OR burns)).af.ĥ0 results were retrieved, of which 4 primary studies were directly relevant to the question. MeSH Terms: Cyanides, Hydroxocobalamin, Inhalation, Ingestion, Burns, Fires. Ovid Medline search from 2000 to April week 1 2015. You wonder whether the administration of an antidote (hydroxocobalamin) could reduce mortality or improve clinical outcome. You recognise that an elevated blood lactate of 12mmol/l makes cyanide poisoning as an important consideration. They are unconscious, hypotensive, and have sooty deposits around their mouth. You are confronted with a patient who has been in a house fire. In patients with suspected, does the administration of lead to improved.

Hydroxocobalamin for cyanide poisoning